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Low Potassium During
Cancer Treatment

Foods high in potassium. Foods to increase potassium. Cancer side effects. Cancer treatment side effects. Foods for hypokalemia.

Potassium is an abundant mineral in the human body, and we obtain it from some fruits, vegetables, legumes, dairy, and fish [1]

Potassium is an essential electrolyte for the body to work properly. Among other functions, some of the potassium roles include:

  • Controls the electrical activity of the heart

  • Ensures proper muscle and nerve function

  • Supports normal blood pressure

  • Vital for protein production and metabolizing carbohydrates

  • It helps move nutrients into cells and waste products out of cells

  • It may reduce the risk of bone loss as we age [2]


Cancer treatment side effects such as vomiting and diarrhea also can result in excessive potassium loss from the digestive tract. Some chemotherapy drugs can also make you have low potassium in your blood. 

When there is a low level of potassium, known as hypokalemia, you may experience muscle weakness and cramps, fatigue, constipation, abnormal heart rhythms, and a slight increase in blood pressure [3]

 

Contrary, excess potassium in the blood, known as hyperkalemia, can cause heart and kidney problems [3]. Therefore, there must be a balance of this mineral in the body. 

The normal adult value for potassium is 3.5-5.2 mEq/L [4].

Hypokalemia is a low serum potassium concentration (< 3.5 mEq/L). Severe hypokalemia is a potassium level lower than 2.5 mEq/L, representing a potentially life-threatening disorder.

Recommended Amounts

The National Academy of Medicine established an Adequate Intake (AI) for potassium.

  • For women 19 years old and older: 2,600 mg potassium daily 

  • For men 19 years old and older: 3,400 mg potassium daily

Foods to Eat to Increase Potassium

The consumption of foods with a high potassium content is essential in diets requiring high levels of this micronutrient, as it often occurs during cancer and cancer treatment. ​If your doctor or dietitian tells you your potassium is too low (hypokalemia), you need to increase the potassium-rich foods in your diet.

  • Cooked leafy greens like Swiss chard and spinach

  • Potatoes, sweet potatoes, cassava, and taro

  • Beets and beet greens 

  • Avocados

  • Winter squash

  • Beans and lentils

  • Bananas and plantains

  • Fish: cod, halibut, snapper, tuna​

  • Dairy and plant-based milks (almond and soy)

  • Tempeh and soybeans 

  • Tomato paste or pureed

  • Yogurt

  • Papaya

  • Cantaloupe

  • Orange 

  • Raisins 

  • Dates

  • Nectarines

What to Drink to Increase Potassium

Many drinks high in potassium can help increase the potassium in your diet. Some drinks have potassium naturally, while others have potassium added during processing. 

  • Coconut water

  • Fruit juices like apricot, tangerine, orange, passion fruit juice

  • Vegetable juices like tomato and carrot juice

  • Cow's milk

  • Soy milk

  • Pedialyte® 

  • Gatorade®  

  • Propel® 

  • Powerade®

What Causes Low Potassium in Cancer

Low potassium (hypokalemia) is a prevalent condition in cancer patients resulting from distinct and specific causes. Chemotherapy can lead to hypokalemia indirectly via side effects of decreased appetite, vomiting, and diarrhea or directly via renal tubular effects.

During cancer treatment, having poor appetite, nausea, and mouth sores can make you eat less than usual, reducing potassium intake. 

Chemotherapy, immunotherapy, and radiation in the abdomen and pelvis may cause side effects of vomiting and diarrhea which can deplete potassium from your body. 

​Specific chemotherapy drugs like cisplatin, carboplatin, ifosfamide, and abiraterone, can deplete potassium leading to hypokalemia [7, 8, 9, 10].

Other causes can also deplete potassium from your body, such as medications such as diuretics and certain antibiotics, excessive use of laxatives, and diseases such as inflammatory bowel and kidney diseases [11].

56 Foods and Drinks High Potassium

 

​Learn about the amount of potassium that The best 56 foods and drinks high in potassium have. These foods and beverages are also excellent sources of other nutrients like protein, magnesium, folate, vitamin C, B vitamins, iron, fiber, and many others. Eating potassium-rich foods every day can help you reach your nutritional goals. 

Note:

 

Do not take potassium supplements unless your healthcare team recommends them, as this can easily cause dangerous blood potassium levels. Discuss with your doctor or oncology dietitian if you feel you are not eating enough nutrients or have cancer treatment side effects. 

Related

References

1. Institute of Medicine. Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate. Washington, DC; 2005.

2. NIH. Office of Dietary Supplements - Potassium. ods.od.nih.gov/factsheets/Potassium-HealthProfessional.

3. Viera AJ, Wouk N. Potassium disorders: Hypokalemia and hyperkalemia. Am Fam Physician 2015;92:487-95. [PubMed abstract]

4. Rastegar A. Serum Potassium. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition.

5. U.S. Department of Agriculture, Agricultural Research Service. FoodData Central, 2019.

6. He FJ, MacGregor GA. Beneficial effects of potassium on human health. Physiol Plant 2008;133:725-35. [PubMed abstract]

7. Rodriguez, M et al. “Refractory potassium repletion due to cisplatin-induced magnesium depletion.” Archives of internal medicine vol. 149,11 (1989)

8. Ma, Yushui et al. “Incidence and physiological mechanism of carboplatin-induced electrolyte abnormality among patients with non-small cell lung cancer.” Oncotarget vol. 8,11 (2017)

9. Das, Sulagna et al. “Partial Fanconi Syndrome Induced by Ifosfamide.” Cureus vol. 11,1 e3947. 23 Jan. 2019, doi:10.7759/cureus.3947

10. Yamamoto, Yutaka et al. “Serious Hypokalemia Associated with Abiraterone Acetate in Patients with Castration-Resistant Prostate Cancer.” Case reports in urology vol. 2018 1414395. 16 Sep. 2018

11. Mayo Clinic. “Low Potassium (Hypokalemia) Causes.” Mayo Clinic, 2018

12. National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Food and Nutrition Board; Committee to Review the Dietary Reference Intakes for Sodium and Potassium. Dietary Reference Intakes for Sodium and Potassium. Edited by Maria Oria et. al., National Academies Press (US), 5 March 2019.

13. U.S. Department of Health and Human Services and U.S. Department of Agriculture. 2015 – 2020 Dietary Guidelines for Americans. 8th Edition. December 2015. 

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