Nutrition Therapy for Fatigue During Cancer
According to the American Cancer Society, fatigue is an extreme feeling of tiredness or lack of energy, often described as being exhausted. Fatigue is common in people with cancer.
Fatigue is prevalent in people with cancer, with 80% to 100% among people receiving treatment, and it persists for many cancer survivors for years after treatment (7).
It is important to remember that fatigue might get better after treatment ends for some but lasts many months to years after treatment for others. Your doctor may refer you to physical therapy for muscle strengthening.
Fatigue is a common symptom of anemia and nutrient deficiencies. If you suspect you have iron, vitamin B12, or vitamin D deficiency, discuss with your healthcare team to check your levels and correct them as needed.
Choosing nutrient-dense foods rich in protein, healthy fats including omega 3, complex carbohydrates rich in fiber, and vitamins and minerals rich in phytonutrients is especially important to combat fatigue (8).
Based on the current evidence, exercise and an anti-inflammatory diet effectively prevent or alleviate cancer-related fatigue during and after cancer treatment (5).
Nutrition Strategies for Fatigue
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Eat at your best time of day. If fatigue worsens in the evening, eat a larger breakfast or lunch.
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Eat every 3-4 hours to keep your energy level constant.
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Choose whole foods like fresh fruits, vegetables, nuts, seeds, beans, lentils, eggs, and fish.
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Stay hydrated by drinking at least 8 cups of fluid daily.
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Keep foods in hand that are quick to prepare or do not require cooking.
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Prepare extra portions of food when you feel well and freeze meals for later.
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Choose nutrition supplements, smoothies, and milkshakes to replace a meal or snack when needed.
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Go for a walk and exercise daily if you are able. Gentle physical activity may help boost energy later in the day.
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Limit naps to 1 hour at a time. Long naps can delay meals and impact sleep at night.
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Use a slow cooker for hands-off cooking.
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Accept help from friends and family.
What Foods to Eat with Fatigue
Clinical studies demonstrate that a balanced diet with fiber contained in whole grains, vegetables, legumes, and fruit, as well as increasing antioxidant vitamins and phytonutrients found in these and omega-3 fatty acid-rich foods, could improve fatigue in patients with cancer and cancer survivors.
Phytonutrient Rich Foods
Red, orange, and yellow foods are rich in lycopene, ellagic acid, quercetin, hesperidin, anthocyanidins, alpha-carotene, beta-carotene, and more.
Beets, cherries, papaya, grapefruit, pomegranates, raspberries, red bell peppers, red grapes, strawberries, tomatoes, watermelon, cantaloupe, butternut squash, carrots, pineapple, apples, peaches, bananas, figs, yellow watermelon, and more
Dark green leafy vegetables are rich in lutein, isoflavones, EGCG, indoles, isothiocyanates, and more.
Kale, microgreens, collard greens, spinach, Bok choy, broccoli, arugula, Swiss chard, beet greens, watercress, endive, Romaine lettuce, turnip greens, and others
White vegetables are high in EGCG, allicin, quercetin, indoles, glucosinolates and other phytonutrients.
Garlic, onions, chives, leeks, mushrooms, cauliflower, pears, white corn, and more
Main phytonutrients in legumes include polyphenols, peptides, saponins, and carotenoids. Beans are high in triterpenoids and flavonoids.
Beans, edamame, lentils, peas, peanuts, and more
Whole grains
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Amaranth, barley, buckwheat, teff, wild rice, quinoa, millet, spelt, bulgur wheat, farro, oats, rye, sorghum, and whole-grain rye (9, 10, 11).
Foods Rich in Omega-3
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Salmon, tuna, sardines, mackerel, trout, halibut, anchovies, herring
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Avocado, olives, walnuts, chia seeds, flax seeds, hemp seeds
Meals and Snacks Suggestions Rich in Nutrients for Fatigue
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Nuts and dry fruit
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Whole grain & nut granola and bars, and fruit bars
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Nuts and seeds
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Greek yogurt topped with berries, nuts, and honey
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Easy to grab fruits like bananas, grapes, pears, apples, and berries
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Peanut butter and crackers and peanut butter sandwich - add slices of bananas or berries
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Overnight oats & chia topped with berries, bananas, nuts, and honey
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Warm cereals like instant oatmeal and polenta
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Cold cereals like All-Bran®, FiberOne™, Kashi®, and Grape-Nuts®
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Add slices of bananas and strawberries for extra nutrients.
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Chia seeds, walnuts, flax seeds for extra calories and nutrients including omega 3
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Add them to oatmeal, yogurt, smoothies, and shakes
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Hummus with olive oil, feta cheese, tomatoes and cucumbers with pita bread
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Guacamole with tortillas, toast or soft bread topped with tomatoes and lime
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Cheese and spinach quesadillas
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Vegetable quiche, veggie omelets, and scrambled eggs with vegetables
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Quinoa salad, wild rice salad, other whole-grain salads
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Lentil soup, bean soup, and chickpea dishes to get high protein and fiber meals
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Turkey, cheese, avocado, and veggie sandwiches
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Chicken salad, tuna salad, and egg and potato salads
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Grilled fish tacos with guacamole and side of black bean soup
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Salmon, tuna, sardines, and smoked trout prepared with avocado, tomatoes, and onions
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Roasted vegetables and sautéed vegetables
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Cooked greens, vegetable soups, and salads with your favorite dishes
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Drinks like turmeric latte or tea, fruit juices, golden milk, and cocoa
What to Drink for Fatigue
A shake can provide enough protein, calories, and other nutrients to nourish the body. On those days when you experience more fatigue, these smoothies are practical and can benefit you as they take a few minutes to prepare. There are also ready-to-drink options in a variety of brands and flavors.
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Milkshakes
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Smoothies
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Protein shakes
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Fruit juices
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Oral nutritional supplements (ONS)
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Kate Farms
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Orgain Organic
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Premier Protein
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What Causes Fatigue in Cancer
According to the ACS, the causes of cancer-related fatigue are often harder to determine because many factors are involved. It might be from cancer itself and a side effect of the cancer treatment.
Severe fatigue is more prevalent in chemotherapy and concurrent chemo-radiation compared to radiotherapy (1).
Based on an NIH review, several causes of fatigue include anemia, infection, fever, pain, dehydration, malnutrition, depression, and poor sleep quality.
Low levels of potassium, phosphorous, calcium, and magnesium are also associated with causes of fatigue in cancer.
Nutrition measures for managing fatigue include medical nutrition therapy which may consist of nutrient repletion with iron, folate, vitamin D, and vitamin B12, among others.
Foods and Drinks to Avoid with Fatigue
Pro-Inflammatory Foods
Foods that cause inflammation should be avoided, which may worsen fatigue. Inflammatory foods may increase your risk of asthma, type 2 diabetes mellitus, heart disease, rheumatoid arthritis, psoriasis, obesity, and cancer (2).
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Fast foods
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Fried foods
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Alcohol
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Artificial sweeteners
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Packaged pastries
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Added sugars like cookies, soft drinks, artificial juices, and so on
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Refined grains like white bread, white rice, white crackers, and white pasta
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Processed meats like sausages, bacon, and hot dogs
Related
References
1. Karthikeyan, Guru et al. “Prevalence of fatigue among cancer patients receiving various anticancer therapies and its impact on quality of life: a cross-sectional study.” (2012):
2. Reddy, Priya, et al. “Metabolic Syndrome Is an Inflammatory Disorder: A Conspiracy Between Adipose Tissue and Phagocytes.” 2019
5. Thong, Melissa S Y et al. “Cancer-Related Fatigue: Causes and Current Treatment Options.” Current treatment options in oncology vol. 21,2 17. 5 Feb. 2020,
6. Bower, Julienne E. “Cancer-related fatigue--mechanisms, risk factors, and treatments.” Nature reviews. Clinical oncology (2014)
7. Haß, Ulrike et al. “Anti-Inflammatory Diets and Fatigue.” Nutrients vol. 11,10 2315. 30 Sep. 2019
8. Inglis, Julia E et al. “Nutritional Interventions for Treating Cancer-Related Fatigue: A Qualitative Review.” Nutrition and cancer vol. 71,1 (2019)
9. Xu, Yujie et al. “Whole grain diet reduces systemic inflammation: A meta-analysis of 9 randomized trials.” Medicine vol. 97,43 (2018)
10. Su, Yan et al. “Mediterranean Diet and Fatigue among Community-Dwelling Postmenopausal Women.” Journal of nutrition in gerontology and geriatrics vol. 41,1 (2022)
11. Zick, Suzanna M et al. “Examination of the association of diet and persistent cancer-related fatigue: a pilot study.” Oncology nursing forum vol. 40,1 (2013)